Objective. To compare chondroitin sulphate (CS) levels aroundmaxillary second premolars, firstmolars, and second molars between\nthe unloaded and the loaded periods and to measure the rates of intrusion of maxillary posterior teeth during segmental posterior\ntooth intrusion. Materials and Methods. In this prospective clinical study, 105 teeth (from 15 patients exhibiting anterior open bite\nand requiring maxillary posterior tooth intrusion) were studied. Competitive ELISA was used to detect CS levels. Dental casts\n(during the unloaded and loaded periods) were scanned, and posterior tooth intrusion distances were measured. Results. During\nthe unloaded period, the median CS levels around maxillary second premolars, first molars, second molars (experimental teeth),\nand mandibular first molars (negative control) were 0.006, 0.055, 0.056, and 0.012 and during the loaded period were 2.592, 5.738,\n4.727, and 0.163 ng/
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